职称 副教授

政治面貌 中共党员

邮箱 heyan@mail.hzau.edu.cn

研究方向 鱼类性腺发育及鱼类繁殖生长的调控研究

教育经历

2003.9-2009.7     武汉大员工命科学学院 分子遗传学     理学博士

1999.9-2003.7     武汉大员工命科学学院 生物技术系     理学学士

主要职历

2015.1-今         十大正规赌官方网站(中国)有限公司    副教授

2016/2-2017/2，美国密歇根大学，分子细胞发育学系，访问学者

2010.7-2014.12    十大正规赌官方网站(中国)有限公司    讲师

科研成果

主持项目：

1. 国家自然科学基金青年基金（31202013）《热激蛋白hsp72促进草鱼糖代谢效率的分子机理研究》。资助金额：22万。 2013.1-2015.12

2. 教育部新教师基金（20120146120007）《热激蛋白hsp72对草鱼胰岛素信号通路的调控及分子机理研究》。资助金额：4万。 2013.1-2014.12

3. 公司自主创新基金 (2011QC075)《Hsp10与IGF1R在黄鳝性逆转过程中的相互作用》。资助金额：6万。 2011.8-2012.12

4. 公司自主创新基金（人才启动）《鳜鱼NPY受体与其食性驯化的研究》。资助金额：3万。2011.1-2012.12

教学成果

1. 参加湖北省教学改革项目《水产生物技术系列课程实验教学的改革与探索》和公司教学改革项目《鱼类基因工程实验教学改革探索》。

2. 发表教学改革论文：

何焱, 杨道兵*, 梁旭方, 袁勇超, 周怡《与现代生物技术相结合的水产类人才培养模式的研究》。 高校生物学教学研究(电子版) 2013年 DOI 10.3868/j.issn 2095-1574.2012.03.015

3. 指导多项SRF项目及国家级大员工创新创业训练计划项目，其中一项获得公司大学2013年国家大员工创新性实验计划项目“十佳项目”称号，并于2014年11月荣获“湖北省第三届高等学校大员工生物实验技能竞赛综合赛”一等奖。

科研成果

1.Yan He*, Jie Fang, Liyao Xue, Junjie Wu, Farman Ullah Dawar, Jie Mei*. Potential contributions of heat shock proteins and related genes in sexual differentiation in yellow catfish( Pelteobagrus fulvidraco). Fish Physiology and Biochemistry. 2017 Feb 28. doi: 10.1007/s10695-016-0303-6. [Epub ahead of print] [IF=1.442] （第一作者/通讯作者）

2.Zhang J, Ma W, He Y*, Wu J, Dawar FU, Ren F, Zhao X, Mei J*. Sex biased expression of ghrelin and GHSR associated with sexual size dimorphism in yellow catfish. Gene, 2016, 578(2):169-76. [IF=2.319]（通讯作者）

3.Limin Zhou, Wei Zheng, Majing Luo, Jing Feng, Zhichun Jin, Yan Wang, Dunlan Zhang, Qiongxiu Tang, Yan He*. dbCerEx: A Web-Based Database for the Analysis of Cervical Cancer Transcriptomes. PLoS ONE 9(6): e99834. doi:10.1371/journal.pone.0099834. 2014. [IF=3.73]（通讯作者）

4.Jie Mei, Wei Yan, Jie Fang, Gailing Yuan, Nan Chen and Yan He*. Identification of a gonad-expression differential gene insulin-like growth factor-1 receptor (Igf1r) in the swamp eel (Monopterus albus). Fish Physiology and Biochemistry. 2014:40:1181-1190. [IF=1.545] (通讯作者)

5.Jie Fang, Hui Wang, Liu Fang, Bin Li, Wenhuan Zhu, Yi Zhou, Jie Mei, Xiaochen Yuan, Liwei Liu and Yan He*. Effects of heat shock treatment on glucose metabolism in grass carp (Ctenopharyngodon idellus) juveniles. Aquaculture. 422-423(2014): 211-217. [IF=2.009] (通讯作者)

6.He Y, Luo M, Yi M, Sheng Y, Cheng Y, Zhou R* and Cheng H*. Identification of a testis-enriched heat shock protein and fourteen members of Hsp70 family in the swamp eel. PLoS ONE 8(6): e65269. doi:10.1371/journal.pone.0065269. 2013. [IF=3.73]（第一作者）

7.Y. He, D. Shen, X. F. Liang*, R. H. Lua and H. Xiao. Genetic polymorphism of LPL and HL and the association with Chinese sturgeon’s performance on formulated diet. Genetics and Molecular Research 2013 12(4): 4559-4566. [IF=0.994]（第一作者）

8.Yan He, Xuan Shang, Junhua Sun, Lei Zhang, Wei Zhao, Yihao Tian, Hanhua Cheng and Rongjia Zhou*. Gonadal apoptosis during sex reversal of the rice field eel: Implications for an evolutionarily conserved role of the molecular chaperone heat shock protein 10. Journal of Experimental Zoology (Molecular and Developmental Evolution).2010. 314B (4):257-266. [IF=3.364]（第一作者）

9.Ma W, Wu J, Zhang J, He Y, Gui J*, Mei J*. Sex differences in the expression of GH/IGF axis genes underlie sexual size dimorphism in the yellow catfish (Pelteobagrus fulvidraco). Sci China Life Sci. 2016, 59(4):431-3.

10.Li GY, Shen D, Liang XF*, He Y, He S. Effects of malachite Green on the mRNA expression of detoxification-related genes in Nile tilapia (Oreochromis niloticus) and other major Chinese freshwater fishes. Environ. Toxicol. Doi/10.1002/tox.20706. 2013. [IF=2.40]

11.Yi Zhou, Xu-Fang Liang, Xiaochen Yuan, Jie Li, Yan He, Liu Fang, Xiaoze Guo, Liwei Liu, Bin Li, Dan Shen. Neuropeptide Y stimulates food intake and regulates metabolism in grass carp, Ctenopharyngodon idellus. Aquaculture. 2013, 380-383, 52-61. [IF=2.009]

12.Liu Fang, Xu-Fang Liang, Yi Zhou, Xiao-Ze Guo, Yan He, Ti-Lin Yi, Li-Wei Liu, Xiao-Chen Yuan, Ya-xiong Tao. Programming Effects of High Carbohydrate Feeding of Larvae on Adult Glucose Metabolism in Zebrafish, Danio rerio. British Journal of Nutrition. 2013 11:1-11. [IF=3.302]

13.Xiaochen Yuan, Yi Zhou, Xu-Fang Liang, Jie Li, Liwei Liu, Bin Li, Yan He, Xiaoze Guo, Liu Fang. Molecular cloning, expression and activity of pyruvate kinase in grass carp Ctenopharyngodon idella: Effects of dietary carbohydrate level. Aquaculture. 2013, 410-411, 32-40. [IF=2.009]

14.Li GY, Yan W, Qiao Q, Chen J, Cai F, He Y, Zhang X*. Global effects of subchronic treatment of microcystin-LR on rat splenetic protein levels. J. Proteomics 77: 383-393. 2012. [IF=5.07]

15.Cheng WX, Liang XF, Shen D, Zhou Q, He Y, He S, Li GY. Seasonal variation of gut Cyanophyta contents and liver GST expression of mud carp (Cirrhina molitorella) and Nile tilapia (Oreochromis niloticus) in the tropical Xiangang Reservoir (Huizhou, China). Chinese Sci Bull 2012, 6:615-622. [IF=1.319]

16.Lu RH, Liang XF, Wang M, Zhou Y, Bai XL, He Y. The role of leptin in lipid metabolism in fatty degenerated hepatocytes of the grass carp Ctenopharyngodon idellus. Fish Physiol Biochem 2012, 38:1759-1774. [IF=1.545]

17.Wang JH, Shen D, Liang XF*, Li GY, He Y, He S. In situ studies on the seasonal variation of gut cyanophyta contens and liver GST expression of silver carp (Hypophthalmichathys molitrix) and grass carp (ctenopharyngodon idella). Fresen. Environ. Bulle. 20:3053-3058. 2011. [IF=0.72]

18.Jinhua Sun, Xuan Shang, Yihao Tian, Wei Zhao, Yan He, Ke Chen, Hanhua Cheng, Rongjia Zhou*. Ubiquitin C-terminal Hydrolase-L1 (UCH-L1) correlates with gonadal transformation in the rice field eel. FEBS J. 2008. 275(2): 242-249. [IF=4.25]

19.Jinhua Sun, Ming Ying, Hui Li, Xuan Shang, Yan He, Ke Chen, Hanhua Cheng, Roujia Zhou*. Role of UCH-L1/ubiquitin in acute testicular ischemia-reperfusion injury. Biochem Biophys Res Commun. 2008. 366(2):539-544. [IF=2.406]

20.Xuan Shang, Jinghua Sun, Yan He, Wei Zhao, Qing Li, Fang Zhou, Bo Chen, Hanhua Cheng, Rongjia Zhou*. Identification and predominant expression of annexin A2 in epithelial-type cells of the rice field eel. J Cell Biochem.2007. 101(3):600-608. [IF=3.062]

21.Hanhua Cheng, Xuan Shang, Yan He, Tao Zhang, Yang Zhao, Rongjia Zhou*, Insight into human sex ratio imbalance: the more boys born, the more infertile men, Reprod.BioMed., 2007. 15 (5):487-494. [IF=2.675]

22.何焱,商璇,程汉华,周荣家*.黄鳝Hprt基因的克隆和表达分析.遗传. 2006. 28(6):677-82.

23.商璇,何焱,张雷,陈波,何春江,程汉华,周荣家*.黄鳝性腺和肾中高度表达的Nup93基因的克隆.遗传. 2006.33(1):41-8.

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