职称 副教授

学位 博士

政治面貌 中共党员

电话 15527280128

邮箱 tujiagang@mail.hzau.edu.cn

研究方向 鱼类病毒致病机理及免疫防治

 教育经历 

2002.9-2003.6 公司 十大正规赌官方网站；

2003.9-2006.6 公司 生命科学技术学院，获学士学位；

2006.9-2011.12 公司 动物科学技术学院动物医学院，获博士学位，导师：陈焕春 教授、金梅林 教授。

 主要职历 

2012.9-2015.5，University of Texas Medical School at Houston, 博士后；

2015.10-2017.9，公司 十大正规赌官方网站，团队博士后；

2017.10-至今，公司 十大正规赌官方网站，副教授。

 科研成果 

主持的科研项目：

1. 聚合酶复合物L-P通过泛素化修饰调节乌鳢水泡病毒增殖和毒力的分子机制研究，国家自然科学基金面上项目，32173014，2022.1-2025.12，58万

2. Leader RNA与N蛋白互作调节乌鳢水泡病毒增殖的分子机制研究，国家自然科学基金面上项目，31972832，2020.1-2023.12，58万

3. 鱼类病毒病疫苗和药物研发，十大正规赌官方网站(中国)有限公司-广东海大集团股份有限公司合作项目，2020.1-2022.12，60万

4. MiR-214在乌鳢水泡病毒感染SSN-1细胞中的调控机制研究，国家自然科学基金青年项目，31602195，2017.1-2019.12，20万

5. 乌鳢水泡病毒P蛋白异构体P3的功能研究，公司自主科技创新基金，2662018QD017，2018.1-2020.12，20万

6. 乌鳢水泡病毒减毒疫苗的研制，十大正规赌官方网站(中国)有限公司-广东海大集团股份有限公司合作项目，2019.1-2019.12，10万

7. 乌鳢水泡病毒调控宿主microRNA的机制研究，中国博士后科学基金，2016M600604，2017.1-2018.12，8万

8. 乌鳢水泡病毒先导RNA与宿主蛋白的互作研究，湖北省自然科学基金，2016CFB233，2017.1-2018.12，3万

9. 乌鳢水泡病毒先导RNA作为核酸疫苗添加剂的研究，农业部渔用药物创制重点实验室开放课题，201501，2016.1-2017.12，4万

发表的第一/通信作者论文：

1. Chi Zhang, An-Qi Liu, Chu Zhang, Lan-Hao Liu, Jianguo Su, Yong-An Zhang*, Jiagang Tu*. MicroRNA miR-722 inhibits cyprinid herpesvirus 3 replication via targeting the viral immune evasion protein ORF89, which negatively regulates IFN by degrading IRF3. Journal of Immunology, 2022, doi: 10.4049/jimmunol.2200025.

2. Lin Jiang, An-Qi Liu, Chu Zhang, Yong-An Zhang*, Jiagang Tu*. Hsp90 regulates GCRV-II proliferation by interacting with VP35 as its receptor and chaperone. Journal of Virology, 2022, e0117522.

3. Chi Zhang, Qing Wang, An-Qi Liu, Chu Zhang, Lan-Hao Liu, Long-Feng Lu, Jiagang Tu*, Yong-An Zhang*. MicroRNA miR-155 inhibits cyprinid herpesvirus 3 replication via regulating AMPK-MAVS-IFN axis. Developmental and Comparative Immunology, 2022, 129: 104335.

4. Yanwei Zhang, Yong-An Zhang*, Jiagang Tu*. Hsp90 is required for snakehead vesiculovirus replication via stabilization of the viral L protein. Journal of Virology, 2021, 95(16): e0059421.

5. Xiangmou Qin#, Shuangshuang Feng#, Yanwei Zhang, Jianguo Su, Li Lin, Yong-An Zhang*, Jiagang Tu*. Leader RNA regulates snakehead vesiculovirus replication via interacting with viral nucleoprotein. RNA Biology, 2021, 18(4): 537-546.

6. Yu Fu, Yong-An Zhang, Jinyu Shen*, Jiagang Tu*. Immunogenicity study of OmpU subunit vaccine against Vibrio mimicus in yellow catfish, Pelteobagrus fulvidraco. Fish and shellfish immunology, 2021, 108: 80-85.

7. Chi Zhang, Jiagang Tu*, Yong-An Zhang*. MicroRNA regulation of viral replication in teleost fish: a review. Reviews in Aquaculture, 2021, 13(3): 1367-1378.

8. Shuangshuang Feng, Jianguo Su, Li Lin*, Jiagang Tu*. Development of a reverse genetics system for snakehead vesiculovirus (SHVV), Virology, 2019, 526: 32-37.

9. Chi Zhang, Ningqiu Li, Xiaozhe Fu, Qiang Lin, Li Lin*, Jiagang Tu*. MiR-214 inhibits snakehead vesiculovirus (SHVV) replication by targeting host GS. Fish and shellfish immunology, 2019, 84:299-303.

10. Chunyan Wang#, Jiagang Tu#, Jun Liu*, Ian J. Molineux*. Structural dynamics of bacteriophage P22 infection initiation revealed by Cryo-electron tomography. Nature Microbiology, 2019, 4(6): 1049-56. 

11. Chi Zhang, Shuangshuang Feng, Wenting Zhang, Nan Chen, Abeer M. Hegazy, Wenjie Chen, Xueqin Liu, Lijuan Zhao, Jun Li, Li Lin*, Jiagang Tu*. MicroRNA miR-214 inhibits snakehead vesiculovirus replication by promoting IFN-a expression via targeting host adenosine 5’-monophosphate-activated protein. Frontiers in immunology, 2017, 8:1775.

12. Chi Zhang, Lizhu Yi, Shuangshuang Feng. Xueqin Liu, Jianguo Su, Li Lin, Jiagang Tu*. MicroRNA miR-214 inhibits snakehead vesiculovirus (SHVV) replication by targeting the coding regions of viral N and P. Journal of General Virology, 2017, 98(7): 1611-1619.

13. Wenjie Chen, Lizhu Yi, Shuangshuang Feng, Lijuan Zhao, Jun Li, Meng Zhou, Rishen Liang, Na Gu, Zaohe Wu, Jiagang Tu*, Li Lin*. Characterization of microRNAs in orange-spotted grouper (Epinephelus coioides) fin cells upon red-spotted grouper nervous necrosis virus infection. Fish and shellfish immunology, 2017, 63:228-236.

14. Wenjie Chen, Lizhu Yi, Shuangshuang Feng, Xiaodan Liu, Muhammad Asim, Yongcan Zhou, Jiangfeng Lan, Sanjie Jiang, Jiagang Tu*, Li Lin*. Transcriptomic profiles of striped snakehead fish cells (SSN-1) infected with red-spotted grouper nervous necrosis virus (RGNNV) with an emphasis on apoptosis pathway. Fish and shellfish immunology, 2017, 60:346-354

15. Muhammad Asim, Sanjie Jiang, Lizhu Yi, Wenjie Chen, Lindan Sun, Lijuan Zhao, Muhammad Nasir Khan Khattak, Jiagang Tu*, Li Lin*. Glutamine is required for red-spotted grouper nervous necrosis virus replication via replenishing the tricarboxylic acid cycle. Virus Research, 2017, 227:245-248.

16. Jiagang Tu, Changxu Tian, Peiqi Zhao, Junxiao Sun, Min Wang, Qixue Fan, Yongchao Yuan*. Identification and profiling of growth-related microRNAs in Chinese perch (Siniperca chuatsi). BMC Genomics, 2017, 18(1): 489.

17. Jiagang Tu, Taehyun Park, Dusustin R. Morado, Kelly T. Hughes, Ian J. Molineux*, Jun Liu*. Dual host specificity of phage SP6 is facilitated by tailspike rotation. Virology, 2017, 507:206-215.

18. Lindan Sun#, Jiagang Tu#, Lizhu Yi, Wenjie Chen, Lijuan Zhao, Yunmao Huang, Rishen Liang, Jun Li, Meng Zhou*, Li Lin*. Pathogenicity of snakehead vesiculovirus in rice field eels (Monopterus albus). Microbial Pathogenesis, 2017, 110:578-585.

19. Madeline M. Farley#, Jiagang Tu#, Daniel B. Kearns, Ian J. Molineux*, Jun Liu*. Ultrastructural analysis of bacteriophage Φ29 during infection of Bacillus subtilis. Journal of Structural Biology, 2017, 197 (2): 163-171.

20. Farman Ullah Dawar#, Jiagang Tu#, Muhammad Nasir Khan Khattak, Jie Mei*, Li Lin*. Cyclophilin A: A Key Factor in Virus Replication and Potential Target for Anti-viral Therapy. Current Issues in Molecular Biology, 2017, 21:1-20.

21. Lindan Sun, Lizhu Yi, Chi Zhang, Xiaodan Liu, Shuangshuang Feng, Wenjie Chen, Jiangfeng Lan, Lijuan Zhao, Jiagang Tu*, Li Lin*. Glutamine was required for snakehead fish vesiculovirus (SHVV) propagation via replenishing the tricarboxylic acid cycle. Journal of General Virology, 2016, 97(11): 2849-2855.

22. Jiagang Tu#, Wenjie Chen#, Xiaozhe Fu, Qiang Lin, Ouqin Chang, Lijuan Zhao. Jiangfeng Lan*, Ningqiu Li*, Li Lin*. Susceptibility of Chinese Perch Brain (CPB) Cell and Mandarin Fish to Red-Spotted Grouper Nervous Necrosis Virus (RGNNV) Infection. Int. J. Mol. Sci., 2016, 17(5): 740. 

23. Xiaodan Liu#, Jiagang Tu#*, Junfa Yuan, Xueqin Liu, Lijuan Zhao, Farman Dawar. Muhammad Khattak, Abeer Hegazy, Nan Chen, Vikram Vakharia, Li Lin*. Identification and Characterization of MicroRNAs in Snakehead Fish Cell Line upon Snakehead Fish Vesiculovirus Infection. Int. J. Mol. Sci., 2016, 17(2): 154.

24. Lijuan Zhao#, Jiagang Tu#, Yulei Zhang, Jinfu Wang, Ling Yang, Weimin Wang, Zaohe Wu, Qinglei Meng*, Li Lin*. Transcriptomic analysis of the head kidney of Topmouth culter (Culter alburnus) infected with Flavobacterium columnare with an emphasis on phagosome pathway. Fish and Shellfish Immunology, 2016, 57:413-418.

25. Jiagang Tu#, Jing Guo#, Anding Zhang#, Wenting Zhang, Zongzheng Zhao, Hongbo Zhou, Cheng Liu, Huanchun Chen, Meilin Jin*. Effects of the C-terminal truncation in NS1 protein of the 2009 pandemic H1N1 influenza virus on host gene expression. PLos One, 2011, 6(10): e26175.

26. Jiagang Tu#, Hongbo Zhou#, Chun Li, Anding Zhang, Xuebo Guo, Wei Zou, Huanchun Chen, Meilin Jin*. Isolation and molecular characterization of equine H3N8 influenza viruses from pigs in China. Arch Virol, 2009, 154(5): 887-890.

27. 伊丽竹，徐镇，林蠡，涂加钢*. miRNA在乌鳢水泡病毒感染月鳢细胞（SSN-1）中的表达变化及其调控作用. 水产学报. 2019, 43(5): 1288-1297.

28. 秘琮然，张永安，涂加钢*. 乌鳢水泡病毒P蛋白异构体的鉴定及其功能初探. 水产学报. 2021.

 备注 

欢迎对鱼类病毒致病机理及免疫防控方向感兴趣的同学报考我的研究生。