职称 副研究员

政治面貌 中共党员

邮箱 heshan@mail.hzau.edu.cn

研究方向 鱼类营养调控与饲料利用遗传改良 

教育经历

2010年9月－2014年12月  获得十大正规赌官方网站(中国)有限公司水生生物学专业博士学位

2013年6月－2014年12月  美国奥本大学兽医学院联合培养

2007年9月－2010年6月   获得暨南大员工命科学技术学院生物化学与分子生物学专业硕士学位

2003年9月－2007年6月   获得暨南大员工命科学技术学院生物科学专业学士学位

主要职历

2015/3-至今，公司，十大正规赌官方网站，副研究员

科研成果

本人主要从事鱼类功能基因组、营养基因组及鱼类摄食代谢调控机理相关研究。现发表学术论文35篇，其中SCI收录24篇，核心期刊11篇，第一作者发表SCI收录论文11篇。以第二发明人申请并授权国家发明专利4项。以第三完成人完成科研成果，由湖北省科技厅科技成果鉴定，认为达国际领先水平。以第六完成人获得2014年度广东科学技术奖应用类二等奖。参与多项国家自然科学基金面上项目，973项目及国家科技支撑计划等。

[1] Shan He, Xu-Fang Liang, Ling Li, Jian Sun, Zheng-Yong Wen, Xiao-Yan Cheng, Ai-Xuan Li, Wen-Jing Cai, Yu-Hui He, Xiao-Chen Yuan, Ya-Ping Wang, Ya-Xiong Tao. 2015. Transcriptome

analysis of food habit transition from carnivory to herbivory in a typical vertebrate herbivore, grass carp Ctenopharyngodon idella. BMC Genomics, 16:15.

[2] Shan He, Ya-Xiong Tao. 2014. Defect in MAPK signaling as a cause for monogenic obesity caused by inactivating mutations in the melanocortin-4 receptor gene. International Journal of Biological Sciences, 10: 1128-1137.

[3] Shan He, Xu-Fang Liang, Jian Sun, Ling Li, Ying Yu, Wei Huang, Chun-Mei Qu, Liang Cao,  Xiao-Li Bai, Ya-Xiong Tao. 2013. Insights into food preference in hybrid F1 of Siniperca chuatsi (♀) × Siniperca scherzeri (♂) mandarin fish through transcriptome analysis. BMC Genomics, 14: 601.

[4] Shan He, Xu-Fang Liang, Ling Li, Wei Huang, Dan Shen, Ya-Xiong Tao. 2013. Gene structure and expression of leptin in Chinese perch. General and Comparative Endocrinology, 194: 183-188.

[5] Shan He, Xu-Fang Liang, Chun-Mei Qu, Wei Huang, Dan Shen, Wen-Bing Zhang, Kang-Sen Mai. 2012. Identification, organ expression and ligand-dependent expression levels of peroxisome proliferator activated receptors in grass carp (Ctenopharyngodon idella). Comparative Biochemistry and Physiology Part C, 155: 381-388.

[6] He S., Liang X.F., Sun J., Shen D. 2013. Induction of liver GST transcriptions by tert-butylhydroquinone reduced microcystin-LR accumulation in Nile tilapia (Oreochromis niloticus). Ecotoxicology and Environmental Safety, 90: 128-135.

[7] Shan He, Xu-Fang Liang, Ling Li, Jian Sun, Dan Shen. 2013. Differential gut growth, gene expression and digestive enzyme activities in young grass carp (Ctenopharyngodon idella) fed with plant and animal diets. Aquaculture, 410-411: 18-24.

[8] He S, Liang XF, Chu WY, Chen DX. 2012. Complete mitochondrial genome of the blind cave barbel Sinocyclocheilus furcodorsalis (Cypriniformes: Cyprinidae). Mitochondr DNA, 23: 429-431.

[9] Shan He, Xu-Fang Liang, Ren Qiang Li, Guan Gui Li, Lin Wang, Dan Shen. 2010. Molecular characterization of heat shock protein 70 genes in the liver of three warm freshwater fishes with differential tolerance to Microcystin-LR. Journal of Biochemistry and Molecular Toxicology, 24(5): 293-302.

[10] He S, Liang XF, Shen D, Zhang WB, Mai KS. 2012. Effects of dietary tert-butylhydroquinone on domoic acid metabolism and transcription of detoxification-related liver genes in red sea bream Pagrus major. Chinese Science Bulletin, 58(16): 1906-1911.

[11] Sun, J.*, He, S.*, Liang, X. F., Li, L., Wen, Z., Zhu, T. 2014. Identification of SNPs in NPY and LEP and the association with food habit domestication traits in mandarin fish. Journal of Genetics, 93: e118-e122 (*并列第一作者)

[12] Yaping Wang, Ying Lu, Yong Zhang, Zemin Ning, Yan Li, Qiang Zhao, Hengyun Lu, Rong Huang, Xiaoqin Xia, Qi Feng, Xufang Liang, Kunyan Liu, Lei Zhang, Tingting Lu, Tao Huang, Danlin Fan, Qijun Weng, Chuanrang Zhu, Yiqi Lu, Wenjun Li, Ziruo Wen, Congcong Zhou, Qilin Tian, Xiaojun Kang, Mijuan Shi, Wanting Zhang, Songhun Jang, Fukuan Du, Shan He, Lanjie Liao, Yongming Li, Bin Gui, Huihui He, Zhen Ning, Cheng Yang, Libo He, Xiaochun Zhang, Shuisheng Li, Wen Huang, Ling Xiao, Haoran Lin, Bin Han, Zuoyan Zhu. 2015. The draft genome of the grass carp (Ctenopharyngodon idellus) provides insights into its evolution and vegetarian adaptation. Nature Genetics, 47: 625-631.

[13] Xu-Fang Liang, Shan He, Dan Shen. 2011. Molecular characterization of β-actin gene in Chinese perch Siniperca chuatsi (Basilewsky). Aquaculture Research, 42(10): 1476-1486.

[14] Liang X-F, Li G-G, He S, Huang Y. 2007. Transcriptional responses of alpha- and rho-class GST genes in the liver of three freshwater fishes intraperitoneally injected with microcystin-LR: relationship of inducible expression and tolerance. Journal of Biochemistry and Molecular Toxicology, 21: 289-298.

[15] Li, L., Liang, X. F., He, S., Li, G., Wen, Z., Cai, W., Shen, D. Transcriptional responses of mu-, pi-and omega-class glutathione S-transferase genes in the hepatopancreas of Cipangopaludina cahayensis exposed to microcystin-LR. Chinese Science Bulletin, 59(25): 3153-3161.

[16] Tilin Yi, Jian Sun, Xufang Liang, Shan He, Ling Li, Zhengyong Wen, Dan Shen. 2013. Effects of polymorphisms in pepsinogen (PEP), amylase (AMY) and trypsin (TRY) genes on food habit domestication traits in mandarin fish. International Journal of Molecular Sciences, 14: 21504-21512.

[17] Yu, Y., Liang, X. F., Li, L., He, S., Wen, Z. Y., Shen, D. 2014. Two homologs of rho-class and polymorphism in alpha-class glutathione S-transferase genes in the liver of three tilapias. Ecotoxicology and environmental safety, 101: 213-219.

[18] Guangyu Li, Dan Shen, Xu-Fang Liang, Yan He, Shan He. 2013. Effects of malachite green on the mRNA expression of detoxification-related genes in Nile tilapia (Oreochromis niloticus) and other major Chinese freshwater fishes. Environmental Toxicology, 28(3): 137-145.

[19] Cheng WX, Liang XF, Shen D, He Y, Li GY, He S. 2012. Seasonal variation of gut Cyanophyta contents and liver GST expression of mud carp (Cirrhina molitorella) and Nile tilapia (Oreochromis niloticus) in the tropical Xiangang Reservoir (Huizhou, China). Chinese Science Bulletin, 57(6): 615-622.

[20] Guo, X., Liang, X. F., Fang, L., Yuan, X., Zhou, Y., He, S., Shen, D. 2014. Effects of lipid-lowering pharmaceutical clofibrate on lipid and lipoprotein metabolism of grass carp (Ctenopharyngodon idellal Val.) fed with the high non-protein energy diets. Fish physiology and biochemistry, DOI: 10.1007/s10695-014-9986-8.

[21] Zhou, Y., Yuan, X., Liang, X. F., Fang, L., Li, J., Guo, X., Bai, X., He, S. 2013. Enhancement of growth and intestinal flora in grass carp: The effect of exogenous cellulase. Aquaculture, 416: 1-7.

[22] Liu Fang, Xu-Fang Liang, Wei-Xuan Cheng, Guan-Gui Li, Shan He, Xiu-Xia Liu, Ying Yu, Dan Shen. 2014. Differential regulation of microcystin detoxification-related liver genes by LPS in two Chinese carps resistant or sensitive to microcystin-LR. Fresenius Environmental Bulletin. (Accepted)

[23] Ling Li, Xu-Fang Liang, Shan He, Jian Sun, Zheng-Yong Wen, Dan Shen, Ya-Xiong Tao. 2015. Genomic structure, tissue expression and single nucleotide polymorphisms of lipoprotein lipase and hepatic lipase genes in Chinese perch. Aquaculture Nutrition, DOI: 10.1111/anu.12292.

[24] Zheng-Yong Wen, Xu-Fang Liang, Shan He, Ling Li, Dan Shen, Ya-Xiong Tao. 2015. Molecular cloning and tissue expression of uncoupling protein 1, 2 and 3 genes in Chinese perch (Siniperca chuatsi). Comparative Biochemistry and Physiology Part B, 185: 24-33.

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